Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells
JR Schafer, TC Salzillo, N Chakravarti… - Journal of Allergy and …, 2019 - Elsevier
Background The mechanism by which natural killer (NK) cell education results in licensed
NK cells with heightened effector function against missing self-targets is not known.
Objective We sought to identify potential mechanisms of enhanced function in licensed
human NK cells. Methods We used expanded human NK cells from killer immunoglobulin-
like receptor (KIR)/HLA–genotyped donors sorted for single-KIR+ cells to generate pure
populations of licensed and unlicensed NK cells. We performed proteomic and gene …
NK cells with heightened effector function against missing self-targets is not known.
Objective We sought to identify potential mechanisms of enhanced function in licensed
human NK cells. Methods We used expanded human NK cells from killer immunoglobulin-
like receptor (KIR)/HLA–genotyped donors sorted for single-KIR+ cells to generate pure
populations of licensed and unlicensed NK cells. We performed proteomic and gene …
